PharmGKB summary: phenytoin pathway.
Article Details
- CitationCopy to clipboard
Thorn CF, Whirl-Carrillo M, Leeder JS, Klein TE, Altman RB
PharmGKB summary: phenytoin pathway.
Pharmacogenet Genomics. 2012 Jun;22(6):466-70. doi: 10.1097/FPC.0b013e32834aeedb.
- PubMed ID
- 22569204 [ View in PubMed]
- Abstract
Not Available
DrugBank Data that Cites this Article
- Drugs
- Drug Enzymes
Drug Enzyme Kind Organism Pharmacological Action Actions Phenytoin Catechol O-methyltransferase Protein Humans NoSubstrateDetails Phenytoin Cytochrome P450 2A6 Protein Humans NoSubstrateDetails Phenytoin Cytochrome P450 2B6 Protein Humans NoSubstrateInducerDetails Phenytoin Cytochrome P450 2C18 Protein Humans NoSubstrateDetails Phenytoin Cytochrome P450 2D6 Protein Humans NoSubstrateDetails Phenytoin Cytochrome P450 2E1 Protein Humans NoSubstrateDetails Phenytoin Cytochrome P450 3A5 Protein Humans NoSubstrateInducerDetails Phenytoin Cytochrome P450 3A7 Protein Humans NoSubstrateInducerDetails Phenytoin Epoxide hydrolase 1 Protein Humans NoSubstrateDetails Phenytoin NAD(P)H dehydrogenase [quinone] 1 Protein Humans NoSubstrateDetails Phenytoin UDP-glucuronosyltransferase 1-1 Protein Humans NoSubstrateInducerDetails Phenytoin UDP-glucuronosyltransferase 1-4 Protein Humans NoSubstrateDetails Phenytoin UDP-glucuronosyltransferase 1-6 Protein Humans NoSubstrateInhibitorDetails Phenytoin UDP-glucuronosyltransferase 1-9 Protein Humans NoSubstrateInhibitorDetails - Drug Transporters
Drug Transporter Kind Organism Pharmacological Action Actions Phenytoin P-glycoprotein 1 Protein Humans UnknownSubstrateDetails - Drug Reactions
Reaction Details - Drug Interactions
Drugs Interaction Integrate drug-drug
interactions in your softwareFosphenytoinFluconazole The serum concentration of Fosphenytoin can be increased when it is combined with Fluconazole. FosphenytoinFosamprenavir The serum concentration of Fosphenytoin can be decreased when it is combined with Fosamprenavir. PhenytoinFluconazole The serum concentration of Phenytoin can be increased when it is combined with Fluconazole. PhenytoinFosamprenavir The serum concentration of Phenytoin can be decreased when it is combined with Fosamprenavir.
