Plazomicin activity against polymyxin-resistant Enterobacteriaceae, including MCR-1-producing isolates.

Article Details

Citation

Denervaud-Tendon V, Poirel L, Connolly LE, Krause KM, Nordmann P

Plazomicin activity against polymyxin-resistant Enterobacteriaceae, including MCR-1-producing isolates.

J Antimicrob Chemother. 2017 Oct 1;72(10):2787-2791. doi: 10.1093/jac/dkx239.

PubMed ID
29091226 [ View in PubMed
]
Abstract

Objectives: Plazomicin, a novel aminoglycoside with in vitro activity against MDR Gram-negative organisms, is under development to treat patients with serious enterobacterial infections. We evaluated the activity of plazomicin and comparators against colistin-resistant enterobacterial isolates. Methods: Susceptibility to plazomicin and comparators was tested by broth microdilution for a collection of 95 colistin-resistant enterobacterial isolates collected from 29 hospitals in eight countries. Forty-two isolates (Klebsiella pneumoniae and Klebsiella oxytoca) possessed chromosomally encoded resistance mechanisms to colistin, 21 isolates (Escherichia coli and Salmonella enterica) expressed the mcr-1 gene, 8 isolates (Serratia, Proteus, Morganella and Hafnia) were intrinsically resistant to colistin and 24 isolates (K. pneumoniae, E. coli and Enterobacter spp.) had undefined, non-mcr-1 mechanisms. Susceptibility profiles were defined according to CLSI for aminoglycosides and to EUCAST for colistin and tigecycline. Results: Plazomicin inhibited 89.5% and 93.7% of the colistin-resistant enterobacterial isolates at 64 and 64 mg/L for amikacin, gentamicin and tobramycin, respectively. Conclusions: Plazomicin displayed potent activity against colistin-resistant clinical enterobacterial isolates, including those expressing the mcr-1 gene. Plazomicin was more active than other aminoglycosides against this collection of isolates. The further development of plazomicin for the treatment of infections due to MDR Enterobacteriaceae is warranted.

DrugBank Data that Cites this Article

Drugs
Drug Targets
DrugTargetKindOrganismPharmacological ActionActions
Plazomicin30S ribosomal protein S11ProteinEnterobacteriaceae bacterium (strain FGI 57)
Yes
Inhibitor
Details