Priapism induced by boceprevir-CYP3A4 inhibition and alpha-adrenergic blockade: case report.

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Hammond KP, Nielsen C, Linnebur SA, Langness JA, Ray G, Maroni P, Kiser JJ

Priapism induced by boceprevir-CYP3A4 inhibition and alpha-adrenergic blockade: case report.

Clin Infect Dis. 2014 Jan;58(1):e35-8. doi: 10.1093/cid/cit673. Epub 2013 Oct 2.

PubMed ID

24092799 [ View in PubMed

]

Abstract

A 44-year-old white man presented to the emergency department with a 3-day history of priapism requiring a surgically performed distal penile shunt. A drug-drug interaction is the suspected cause whereby CYP3A4 inhibition by boceprevir led to increased exposures of doxazosin, tamsulosin, and/or quetiapine, resulting in additional alpha-adrenergic blockade.

DrugBank Data that Cites this Article

Drugs

Doxazosin

Drug Enzymes

Drug	Enzyme	Kind	Organism	Pharmacological Action	Actions
Doxazosin	Cytochrome P450 2C19	Protein	Humans	Unknown	Substrate	Details
Doxazosin	Cytochrome P450 2D6	Protein	Humans	Unknown	Substrate	Details
Doxazosin	Cytochrome P450 3A4	Protein	Humans	No	Substrate	Details

Drug Interactions

Drugs	Interaction
Integrate drug-drug interactions in your software
Boceprevir Efavirenz	The serum concentration of Boceprevir can be decreased when it is combined with Efavirenz.
Doxazosin Methimazole	The metabolism of Doxazosin can be decreased when combined with Methimazole.
Doxazosin Delavirdine	The metabolism of Doxazosin can be decreased when combined with Delavirdine.
Doxazosin Midostaurin	The metabolism of Doxazosin can be decreased when combined with Midostaurin.
Doxazosin Danazol	The metabolism of Doxazosin can be decreased when combined with Danazol.