Role of cytochrome P450 in drug interactions.
Article Details
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Bibi Z
Role of cytochrome P450 in drug interactions.
Nutr Metab (Lond). 2008 Oct 18;5:27. doi: 10.1186/1743-7075-5-27.
- PubMed ID
- 18928560 [ View in PubMed]
- Abstract
Drug-drug interactions have become an important issue in health care. It is now realized that many drug-drug interactions can be explained by alterations in the metabolic enzymes that are present in the liver and other extra-hepatic tissues. Many of the major pharmacokinetic interactions between drugs are due to hepatic cytochrome P450 (P450 or CYP) enzymes being affected by previous administration of other drugs. After coadministration, some drugs act as potent enzyme inducers, whereas others are inhibitors. However, reports of enzyme inhibition are very much more common. Understanding these mechanisms of enzyme inhibition or induction is extremely important in order to give appropriate multiple-drug therapies. In future, it may help to identify individuals at greatest risk of drug interactions and adverse events.
DrugBank Data that Cites this Article
- Drug Enzymes
Drug Enzyme Kind Organism Pharmacological Action Actions Aprobarbital Cytochrome P450 3A4 Protein Humans UnknownInducerDetails - Drug Interactions
Drugs Interaction Integrate drug-drug
interactions in your softwareAmlodipineCimetidine The serum concentration of Amlodipine can be increased when it is combined with Cimetidine. BepridilCimetidine The serum concentration of Bepridil can be increased when it is combined with Cimetidine. CarvedilolCimetidine The serum concentration of Carvedilol can be increased when it is combined with Cimetidine. CinnarizineCimetidine The serum concentration of Cinnarizine can be increased when it is combined with Cimetidine. ClevidipineCimetidine The serum concentration of Clevidipine can be increased when it is combined with Cimetidine.