Anastrozole.

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Kelly CM, Buzdar AU

Anastrozole.

Expert Opin Drug Saf. 2010 Nov;9(6):995-1003. doi: 10.1517/14740338.2010.515977.

PubMed ID

20923259 [ View in PubMed

]

Abstract

IMPORTANCE OF THE FIELD: Anastrozole is a third-generation aromatase inhibitor used in the adjuvant setting for the treatment of hormone receptor-positive breast cancer. Several adjuvant randomized trials have reported greater efficacy for anastrozole when compared to tamoxifen. AREAS COVERED IN THIS REVIEW: This review discusses the mechanism of action of anastrozole; pharmacokinetic and pharmacodynamic characteristics; results of randomized controlled trials of anastrozole compared to tamoxifen in the adjuvant treatment of postmenopausal women with hormone receptor-positive breast cancer and the safety profile of anastrozole compared to tamoxifen. WHAT THE READER WILL GAIN: The reader will gain an understanding of the basic pharmacology of anastrozole, efficacy data from clinical trials comparing anastrozole to tamoxifen, safety profile of anastrozole and ongoing areas of research. TAKE HOME MESSAGE: The adverse effects of anastrozole.

DrugBank Data that Cites this Article

Drugs

Anastrozole

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Anastrozole	Cytochrome P450 19A1	Protein	Humans	Yes	Inhibitor	Details

Drug Interactions

Drugs	Interaction
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