Pharmacotherapy of essential tremor.
Article Details
- CitationCopy to clipboard
Hedera P, Cibulcik F, Davis TL
Pharmacotherapy of essential tremor.
J Cent Nerv Syst Dis. 2013 Dec 22;5:43-55. doi: 10.4137/JCNSD.S6561.
- PubMed ID
- 24385718 [ View in PubMed]
- Abstract
Essential tremor (ET) is a common movement disorder but its pathogenesis remains poorly understood. This has limited the development of effective pharmacotherapy. The current therapeutic armamentaria for ET represent the product of careful clinical observation rather than targeted molecular modeling. Here we review their pharmacokinetics, metabolism, dosing, and adverse effect profiles and propose a treatment algorithm. We also discuss the concept of medically refractory tremor, as therapeutic trials should be limited unless invasive therapy is contraindicated or not desired by patients.
DrugBank Data that Cites this Article
- Drugs
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Primidone GABA(A) Receptor (Protein Group) Protein group Humans YesPositive allosteric modulatorDetails - Drug Enzymes
Drug Enzyme Kind Organism Pharmacological Action Actions Primidone Cytochrome P450 1A2 Protein Humans UnknownInducerDetails Primidone Cytochrome P450 2C9 Protein Humans UnknownSubstrateInducerDetails Primidone Cytochrome P450 3A4 Protein Humans UnknownInducerDetails - Drug Interactions
Drugs Interaction Integrate drug-drug
interactions in your softwareAmobarbitalPrimidone The risk or severity of adverse effects can be increased when Primidone is combined with Amobarbital. AmobarbitalMethylphenobarbital The risk or severity of adverse effects can be increased when Methylphenobarbital is combined with Amobarbital. AmobarbitalPhenobarbital The risk or severity of adverse effects can be increased when Phenobarbital is combined with Amobarbital. ButabarbitalPrimidone The risk or severity of adverse effects can be increased when Primidone is combined with Butabarbital. ButabarbitalMethylphenobarbital The risk or severity of adverse effects can be increased when Methylphenobarbital is combined with Butabarbital.