PharmGKB summary: pathways of acetaminophen metabolism at the therapeutic versus toxic doses.

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Mazaleuskaya LL, Sangkuhl K, Thorn CF, FitzGerald GA, Altman RB, Klein TE

PharmGKB summary: pathways of acetaminophen metabolism at the therapeutic versus toxic doses.

Pharmacogenet Genomics. 2015 Aug;25(8):416-26. doi: 10.1097/FPC.0000000000000150.

PubMed ID

26049587 [ View in PubMed

]

Abstract

Not Available

Drugs

Acetaminophen

Drug Enzymes

Drug	Enzyme	Kind	Organism	Pharmacological Action	Actions
Acetaminophen	Cytochrome P450 1A2	Protein	Humans	Unknown	Substrate	Details

Drug Reactions

Reaction
Acetaminophen DB00316 Cytochrome P450 2E1 Cytochrome P450 3A4 Cytochrome P450 1A2 Cytochrome P450 2D6 Cytochrome P450 2A6 NAPQI DBMET00243	Details
Acetaminophen DB00316 UDP-glucuronosyltransferase 1-9 UDP-glucuronosyltransferase 1-6 UDP-glucuronosyltransferase 1-1 UDP-glucuronosyltransferase 2B15 UDP-glucuronosyltransferase 1-10 Acetaminophen glucuronide DBMET00580	Details
Acetaminophen DB00316 Sulfotransferase 1A1 Sulfotransferase 1A3/1A4 Bile salt sulfotransferase Acetaminophen sulfate DBMET00653	Details

Drug Interactions

Drugs	Interaction
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Acetaminophen Isoniazid	Isoniazid may increase the hepatotoxic activities of Acetaminophen.

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