Interactions between hormonal contraception and antiepileptic drugs: Clinical and mechanistic considerations.

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Reimers A, Brodtkorb E, Sabers A

Interactions between hormonal contraception and antiepileptic drugs: Clinical and mechanistic considerations.

Seizure. 2015 May;28:66-70. doi: 10.1016/j.seizure.2015.03.006. Epub 2015 Mar 20.

PubMed ID

25843765 [ View in PubMed

]

Abstract

Antiepileptic drugs (AEDs) and hormonal contraceptives may affect each other's metabolism and clinical efficacy. Loss of seizure control and unplanned pregnancy may occur when these compounds are used concomitantly. Although a large number of available preparations yield a plethora of possible drug combinations, most of these drug interactions are predictable and, thus, avoidable. Unfortunately, there is a substantial lack of data regarding the newer AEDs. Detailed understanding of these issues is necessary for those who prescribe AEDs and/or hormonal contraception to women with epilepsy, as well as for those who provide comprehensive care, education and counseling to them, in order to reduce the unacceptably high number of unplanned pregnancies among women with epilepsy.

DrugBank Data that Cites this Article

Drug Enzymes

Drug	Enzyme	Kind	Organism	Pharmacological Action	Actions
Norethynodrel	Cytochrome P450 3A4	Protein	Humans	No	Substrate	Details

Drug Interactions

Drugs	Interaction
Integrate drug-drug interactions in your software
Lamotrigine Segesterone acetate	The metabolism of Lamotrigine can be increased when combined with Segesterone acetate.