Role of P glycoprotein in absorption of novel antimalarial drugs.

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Crowe A, Ilett KF, Karunajeewa HA, Batty KT, Davis TM

Role of P glycoprotein in absorption of novel antimalarial drugs.

Antimicrob Agents Chemother. 2006 Oct;50(10):3504-6. doi: 10.1128/AAC.00708-06. Epub 2006 Aug 17.

PubMed ID
16917012 [ View in PubMed
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Abstract

Bidirectional transport of four novel antimalarial compounds was determined using Caco-2 cell monolayers. P glycoprotein-mediated efflux was greatest for pyronaridine (5 to 20 microM) and low for naphthoquine (5 microM). With 20 microM naphthoquine, net efflux was blocked, suggesting saturation of the transporter. Piperaquine and dihydroartemisinin were not transported by the system.

DrugBank Data that Cites this Article

Drug Transporters
DrugTransporterKindOrganismPharmacological ActionActions
ChloroquineP-glycoprotein 1ProteinHumans
Unknown
Substrate
Inhibitor
Details
HydroxychloroquineP-glycoprotein 1ProteinHumans
Unknown
Inhibitor
Details