Alpha-2 adrenergic receptor agonists: a review of current clinical applications.

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Giovannitti JA Jr, Thoms SM, Crawford JJ

Alpha-2 adrenergic receptor agonists: a review of current clinical applications.

Anesth Prog. 2015 Spring;62(1):31-9. doi: 10.2344/0003-3006-62.1.31.

PubMed ID

25849473 [ View in PubMed

]

Abstract

The alpha-2 adrenergic receptor agonists have been used for decades to treat common medical conditions such as hypertension; attention-deficit/hyperactivity disorder; various pain and panic disorders; symptoms of opioid, benzodiazepine, and alcohol withdrawal; and cigarette craving. (1) However, in more recent years, these drugs have been used as adjuncts for sedation and to reduce anesthetic requirements. This review will provide an historical perspective of this drug class, an understanding of pharmacological mechanisms, and an insight into current applications in clinical anesthesiology.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Tizanidine	Alpha-2 adrenergic receptors (Protein Group)	Protein group	Humans	Unknown	Agonist	Details

Drug Interactions

Drugs	Interaction
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Epinephrine Promethazine	Promethazine may decrease the vasoconstricting activities of Epinephrine.