Cabergoline : a review of its use in the treatment of Parkinson's disease.

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Curran MP, Perry CM

Cabergoline : a review of its use in the treatment of Parkinson's disease.

Drugs. 2004;64(18):2125-41.

PubMed ID

15341508 [ View in PubMed

]

Abstract

Cabergoline is a synthetic ergoline dopamine agonist with a high affinity for dopamine D2 receptors and a long elimination half-life. This agent provides continuous dopaminergic stimulation with once-daily administration. Adjuvant oral cabergoline is usually well tolerated and effective in controlling symptoms in patients with advanced Parkinson's disease experiencing response fluctuations to long-term levodopa therapy. In patients with early Parkinson's disease, cabergoline (with or without levodopa) is well tolerated and effective in controlling disease symptoms, and may reduce the risk of developing drug-induced motor complications. Data from two pharmacoeconomic analyses suggest that cabergoline may be a cost-effective treatment option versus levodopa in patients with early Parkinson's disease, and highlight the need for further evaluation of the drug in this indication.

DrugBank Data that Cites this Article

Drugs

Cabergoline

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Cabergoline	Dopamine D2 receptor	Protein	Humans	Yes	Agonist	Details