Lack of effect of atenolol on the pharmacokinetics of theophylline.
Article Details
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Cerasa LA, Bertino JS Jr, Ludwig EA, Savliwala M, Middleton E Jr, Slaughter RL
Lack of effect of atenolol on the pharmacokinetics of theophylline.
Br J Clin Pharmacol. 1988 Dec;26(6):800-2.
- PubMed ID
- 3242586 [ View in PubMed]
- Abstract
The effects of 3 days of pretreatment with cardioselective doses of atenolol on theophylline pharmacokinetics were determined. Nine healthy nonsmoking male volunteers received 6 mg kg-1 i.v. aminophylline under baseline conditions and after both 50 mg day-1 and 100 mg day-1 atenolol. Theophylline clearance, volume of distribution and half-life were not influenced by atenolol pretreatment. These data indicate that cardioselective doses of atenolol do not alter the pharmacokinetics of theophylline.
DrugBank Data that Cites this Article
- Drug Enzymes
Drug Enzyme Kind Organism Pharmacological Action Actions Xanthine Cytochrome P450 1A2 Protein Humans NoSubstrateDetails - Drug Interactions
Drugs Interaction Integrate drug-drug
interactions in your softwareAminophyllineEsmolol The risk or severity of adverse effects can be increased when Esmolol is combined with Aminophylline. AminophyllineBetaxolol The risk or severity of adverse effects can be increased when Betaxolol is combined with Aminophylline. AminophyllineAtenolol The risk or severity of adverse effects can be increased when Atenolol is combined with Aminophylline. AminophyllineTimolol The risk or severity of adverse effects can be increased when Timolol is combined with Aminophylline. AminophyllineSotalol The risk or severity of adverse effects can be increased when Sotalol is combined with Aminophylline.