The Impact of CYP1A2 and CYP2E1 Genes Polymorphism on Theophylline Response.
Article Details
- CitationCopy to clipboard
Sutrisna E
The Impact of CYP1A2 and CYP2E1 Genes Polymorphism on Theophylline Response.
J Clin Diagn Res. 2016 Nov;10(11):FE01-FE03. doi: 10.7860/JCDR/2016/21067.8914. Epub 2016 Nov 1.
- PubMed ID
- 28050398 [ View in PubMed]
- Abstract
Theophylline is a medicine with narrow therapeutic index. This implies that a small change in dosage would cause side effects. Theophylline is metabolized by CYP1A2 and CYP2E1. The aim of this review is to know the impact of CYP1A2 and CYP2E1 genes polymorphism on theophylline response. The review was done by searching literature in Pubmed and Science Direct databases with keywords 'polymorphism', 'pharmacogenetic', 'CYP1A2', 'CYP2E1' and 'theophylline'. There were 5 research articles from Pubmed and 65 articles (21 research articles, 23 review articles and 21 book chapters) from Science Direct. The exclusion criteria were - articles discussing about polymorphism but not CYP1A2 or CYP2E1, the ones with a mention of theophylline but not about its metabolism, articles on CYP1A2 and/or 2E1 polymorphism but not on the effect on theophylline. Thus, 33 articles were reviewed due to their suitability. The review discusses the influence of polymorphism of CYP1A2 and CYP2E1 genes on theophylline response.
DrugBank Data that Cites this Article
- Drug Enzymes
Drug Enzyme Kind Organism Pharmacological Action Actions Orphenadrine Cytochrome P450 2E1 Protein Humans UnknownInhibitorDetails Theophylline Cytochrome P450 2E1 Protein Humans UnknownSubstrateDetails - Drug Interactions
Drugs Interaction Integrate drug-drug
interactions in your softwareAminophyllinePentoxifylline The serum concentration of Aminophylline can be increased when it is combined with Pentoxifylline. BromotheophyllinePentoxifylline The serum concentration of Bromotheophylline can be increased when it is combined with Pentoxifylline. CaffeinePentoxifylline The serum concentration of Caffeine can be increased when it is combined with Pentoxifylline. DyphyllinePentoxifylline The serum concentration of Dyphylline can be increased when it is combined with Pentoxifylline. LomifyllinePentoxifylline The serum concentration of Lomifylline can be increased when it is combined with Pentoxifylline.