Folic Acid and Epilepsy.

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Morrell MJ

Folic Acid and Epilepsy.

Epilepsy Curr. 2002 Mar;2(2):31-34. doi: 10.1046/j.1535-7597.2002.00017.x.

PubMed ID

15309159 [ View in PubMed

]

Abstract

Folic acid has been a topic of discussion within the epilepsy community for several decades. Folic acid was initially suspected to be epileptogenic (1), but that concern has been resolved, as research has demonstrated that folic acid in less than supraphysiologic concentrations does not promote seizures. Epileptologists are now concerned that folic acid may be too low in persons with epilepsy taking some antiepileptic drugs (AEDs). Low serum and red blood cell levels of folic acid in women of childbearing potential increase the risk of fetal birth defects. For men and women, low levels of folic acid are associated with elevated homocysteine and an increased risk for cardiovascular disease. A convincing argument now develops that routine folic acid supplementation is important for women and men receiving AEDs.

DrugBank Data that Cites this Article

Drugs

Folic acid

Drug Interactions

• Approved
• Vet approved
• Nutraceutical
• Illicit
• Withdrawn
• Investigational
• Experimental
• All Drugs

Drugs	Interaction
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Folic acid Carbamazepine	The serum concentration of Folic acid can be decreased when it is combined with Carbamazepine.
Leucovorin Carbamazepine	The serum concentration of Leucovorin can be decreased when it is combined with Carbamazepine.
Levoleucovorin Carbamazepine	The serum concentration of Levoleucovorin can be decreased when it is combined with Carbamazepine.
Levomefolic acid Carbamazepine	The serum concentration of Levomefolic acid can be decreased when it is combined with Carbamazepine.
Methylphenobarbital Levomefolic acid	The serum concentration of the active metabolites of Methylphenobarbital can be reduced when Methylphenobarbital is used in combination with Levomefolic acid resulting in a loss in efficacy.