Binding of CYP2C9 with diverse drugs and its implications for metabolic mechanism.
Article Details
- CitationCopy to clipboard
Wang JF, Yan JY, Wei DQ, Chou KC
Binding of CYP2C9 with diverse drugs and its implications for metabolic mechanism.
Med Chem. 2009 May;5(3):263-70.
- PubMed ID
- 19442216 [ View in PubMed]
- Abstract
Cytochrome P450 2C9 (CYP2C9) is an important member of the cytochrome P450 enzyme superfamily with responsibility for metabolizing many important exogenous and endogenous compounds in many species of microorganisms, plants and animals. CYP2C9 is related to the oxidative of 16% of all therapeutics in current clinical use and has adverse drug effects, such as, enzyme induction and inhibition. In order to understand the metabolic mechanism of various drugs, two crystal structures of CYP2C9 have been studied, and their structural differences and structure-activity relationships with the drugs of Fluoxetine, Ibuprofen, Naproxen, Suprofen, and Mefenamic acid were investigated. By a series of docking studies and MD simulations, the binding pockets of CYP2C9 for the five drugs are explicitly defined that will be very useful for conducting mutagenesis studies, providing insights into the metabolic mechanism, which may be of relevance to the personalized drug.
DrugBank Data that Cites this Article
- Drug Enzymes
Drug Enzyme Kind Organism Pharmacological Action Actions Fluoxetine Cytochrome P450 2C9 Protein Humans UnknownSubstrateInhibitorDetails Mefenamic acid Cytochrome P450 2C9 Protein Humans UnknownSubstrateInhibitorDetails Suprofen Cytochrome P450 2C9 Protein Humans UnknownSubstrateInhibitorDetails - Drug Interactions
Drugs Interaction Integrate drug-drug
interactions in your softwareFluoxetinePeginterferon alfa-2b The serum concentration of Fluoxetine can be decreased when it is combined with Peginterferon alfa-2b.