Drug interactions between hormonal contraceptives and antiretrovirals.
Article Details
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Nanda K, Stuart GS, Robinson J, Gray AL, Tepper NK, Gaffield ME
Drug interactions between hormonal contraceptives and antiretrovirals.
AIDS. 2017 Apr 24;31(7):917-952. doi: 10.1097/QAD.0000000000001392.
- PubMed ID
- 28060009 [ View in PubMed]
- Abstract
OBJECTIVE: To summarize published evidence on drug interactions between hormonal contraceptives and antiretrovirals. DESIGN: Systematic review of the published literature. METHODS: We searched PubMed, POPLINE, and EMBASE for peer-reviewed publications of studies (in any language) from inception to 21 September 2015. We included studies of women using hormonal contraceptives and antiretrovirals concurrently. Outcomes of interest were effectiveness of either therapy, toxicity, or pharmacokinetics. We used standard abstraction forms to summarize and assess strengths and weaknesses. RESULTS: Fifty reports from 46 studies were included. Most antiretrovirals whether used for therapy or prevention, have limited interactions with hormonal contraceptive methods, with the exception of efavirenz. Although depot medroxyprogesterone acetate is not affected, limited data on implants and combined oral contraceptive pills suggest that efavirenz-containing combination antiretroviral therapy may compromise contraceptive effectiveness of these methods. However, implants remain very effective despite such drug interactions. Antiretroviral plasma concentrations and effectiveness are generally not affected by hormonal contraceptives. CONCLUSION: Women taking antiretrovirals, for treatment or prevention, should not be denied access to the full range of hormonal contraceptive options, but should be counseled on the expected rates of unplanned pregnancy associated with all contraceptive methods, in order to make their own informed choices.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Cobicistat Cytochrome P450 3A4 Protein Humans YesInhibitorDetails - Drug Interactions
Drugs Interaction Integrate drug-drug
interactions in your softwareCyproterone acetateAtazanavir The serum concentration of Cyproterone acetate can be increased when it is combined with Atazanavir. Cyproterone acetateNafcillin The metabolism of Cyproterone acetate can be increased when combined with Nafcillin. Cyproterone acetateModafinil The metabolism of Cyproterone acetate can be increased when combined with Modafinil. Cyproterone acetateEtravirine The metabolism of Cyproterone acetate can be increased when combined with Etravirine. Cyproterone acetateAvasimibe The metabolism of Cyproterone acetate can be increased when combined with Avasimibe.