Physiological and pharmacological aspects of adrenergic receptor classification.
Article Details
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Ariens EJ, Simonis AM
Physiological and pharmacological aspects of adrenergic receptor classification.
Biochem Pharmacol. 1983 May 15;32(10):1539-45.
- PubMed ID
- 6134529 [ View in PubMed]
- Abstract
The questions raised are: what is the physiological or pharmacological basis for the differentiation into beta 1- and beta 2-, and alpha 1- and alpha 2-adrenergic receptors?; and do the neurotransmitter norepinephrine and the hormone epinephrine differ in their receptors? On the basis of a preference of beta 2- and alpha 2-adrenergic receptors for epinephrine, the hormone, and of beta 1-and alpha 1-receptors for norepinephrine, the neurotransmitter, it was postulated that the alpha 2- and beta 2-receptors are predominantly epinephrinergic in nature and located extrajunctionally and presynaptically whereas the alpha 1- and beta 1-receptors are predominantly norepinephrinergic in nature and located postsynaptically in the sympathetic terminal junction. The alpha 2- and beta 2-character of the presynaptic receptors matches that of the corresponding extrajunctional receptors. This indicates that a circulating catecholamine, namely epinephrine, is involved in the regulation of adrenergic transmitter release.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Epinephrine Alpha-2A adrenergic receptor Protein Humans YesAgonistDetails Epinephrine Alpha-2B adrenergic receptor Protein Humans YesAgonistDetails