Opioid therapies and cytochrome p450 interactions.

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Gudin J

Opioid therapies and cytochrome p450 interactions.

J Pain Symptom Manage. 2012 Dec;44(6 Suppl):S4-14. doi: 10.1016/j.jpainsymman.2012.08.013.

PubMed ID

23218233 [ View in PubMed

]

Abstract

Adverse drug reactions are common and associated with substantial economic and human costs. Particularly among older adult populations, preventable adverse drug reactions are often caused by drug-drug interactions. All analgesics have side effect profiles and many have known drug-drug interactions. Opioids are recognized as a necessary option for managing moderate-to-severe pain, yet many opioid side effects can be enhanced by metabolic interactions within the liver, involving other drugs, diseases, or genetics.

DrugBank Data that Cites this Article

Drug Enzymes

Drug	Enzyme	Kind	Organism	Pharmacological Action	Actions
Amoxapine	Cytochrome P450 2D6	Protein	Humans	Unknown	Substrate Inhibitor	Details
Hydromorphone	UDP-glucuronosyltransferase 1-3	Protein	Humans	No	Substrate	Details
Hydromorphone	UDP-glucuronosyltransferase 2B7	Protein	Humans	No	Substrate	Details

Drug Reactions

Reaction
Hydromorphone DB00327 UDP-glucuronosyltransferase 1-3 UDP-glucuronosyltransferase 2B7 Hydromorphone-3-glucuronide DBMET00866	Details

Drug Interactions

• Approved
• Vet approved
• Nutraceutical
• Illicit
• Withdrawn
• Investigational
• Experimental
• All Drugs

Drugs	Interaction
Integrate drug-drug interactions in your software
Hydrocodone Mitotane	The metabolism of Hydrocodone can be increased when combined with Mitotane.
Hydrocodone Rifampicin	The metabolism of Hydrocodone can be increased when combined with Rifampicin.
Hydrocodone Enzalutamide	The metabolism of Hydrocodone can be increased when combined with Enzalutamide.
Hydrocodone Lumacaftor	The metabolism of Hydrocodone can be increased when combined with Lumacaftor.
Hydrocodone Apalutamide	The metabolism of Hydrocodone can be increased when combined with Apalutamide.