Interaction between lopinavir/ritonavir and warfarin.

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Hughes CA, Freitas A, Miedzinski LJ

Interaction between lopinavir/ritonavir and warfarin.

CMAJ. 2007 Aug 14;177(4):357-9. doi: 10.1503/cmaj.061284.

PubMed ID

17698824 [ View in PubMed

]

Abstract

Drug interactions involving protease inhibitors are common. Protease inhibitors are well known inhibitors of the 3A4 isozyme of cytochrome P450. Select protease inhibitors, including co-formulated lopinavir/ritonavir, may induce glucuronidation or the activity of other CYP450 isozymes. We describe the case of a patient taking warfarin who experienced a significantly decreased international normalized ratio after the initiation of antiretroviral therapy that included lopinavir/ritonavir. We review the possible mechanisms of this interaction and the reported interactions between warfarin and other protease inhibitors.

DrugBank Data that Cites this Article

Drug Enzymes

Drug	Enzyme	Kind	Organism	Pharmacological Action	Actions
Lopinavir	Cytochrome P450 2C9	Protein	Humans	Unknown	Inhibitor Inducer	Details
Ritonavir	Cytochrome P450 2C19	Protein	Humans	No	Inducer	Details

Drug Interactions

• Approved
• Vet approved
• Nutraceutical
• Illicit
• Withdrawn
• Investigational
• Experimental
• All Drugs

Drugs	Interaction
Integrate drug-drug interactions in your software
Acenocoumarol Ritonavir	The serum concentration of Acenocoumarol can be decreased when it is combined with Ritonavir.
Warfarin Ritonavir	The serum concentration of Warfarin can be decreased when it is combined with Ritonavir.