Interaction between lopinavir/ritonavir and warfarin.

Article Details

Citation

Hughes CA, Freitas A, Miedzinski LJ

Interaction between lopinavir/ritonavir and warfarin.

CMAJ. 2007 Aug 14;177(4):357-9. doi: 10.1503/cmaj.061284.

PubMed ID
17698824 [ View in PubMed
]
Abstract

Drug interactions involving protease inhibitors are common. Protease inhibitors are well known inhibitors of the 3A4 isozyme of cytochrome P450. Select protease inhibitors, including co-formulated lopinavir/ritonavir, may induce glucuronidation or the activity of other CYP450 isozymes. We describe the case of a patient taking warfarin who experienced a significantly decreased international normalized ratio after the initiation of antiretroviral therapy that included lopinavir/ritonavir. We review the possible mechanisms of this interaction and the reported interactions between warfarin and other protease inhibitors.

DrugBank Data that Cites this Article

Drug Enzymes
DrugEnzymeKindOrganismPharmacological ActionActions
LopinavirCytochrome P450 2C9ProteinHumans
Unknown
Inhibitor
Inducer
Details
RitonavirCytochrome P450 2C19ProteinHumans
No
Inducer
Details
Drug Interactions
DrugsInteraction
Acenocoumarol
Ritonavir
The serum concentration of Acenocoumarol can be decreased when it is combined with Ritonavir.
Warfarin
Ritonavir
The serum concentration of Warfarin can be decreased when it is combined with Ritonavir.
Interactions
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