Interactions between the cytochrome P450 system and the second-generation antipsychotics.
Article Details
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Prior TI, Baker GB
Interactions between the cytochrome P450 system and the second-generation antipsychotics.
J Psychiatry Neurosci. 2003 Mar;28(2):99-112.
- PubMed ID
- 12670127 [ View in PubMed]
- Abstract
Awareness of the metabolism of second-generation antipsychotics by the cytochrome P450 (CYP) system can inform the clinician about how to avoid and manage drug-drug interactions involving these enzymes. Clozapine is metabolized primarily by CYP1A2, with additional contributions by CYP2C19, CYP2D6 and CYP3A4. Risperidone is metabolized primarily by CYP2D6 and to a lesser extent by CYP3A4. Olanzapine is metabolized primarily by CYP1A2 and to a lesser extent by CYP2D6. Quetiapine and ziprasidone are metabolized by CYP3A4. At the usual clinical doses, these drugs appear not to significantly affect the metabolism of other medications. There is, however, a lack of in vivo metabolic data, especially for the 3 newest second-generation antipsychotics: olanzapine, quetiapine and ziprasidone.
DrugBank Data that Cites this Article
- Drug Enzymes
Drug Enzyme Kind Organism Pharmacological Action Actions Clozapine Cytochrome P450 2D6 Protein Humans NoSubstrateInhibitorDetails Risperidone Cytochrome P450 3A4 Protein Humans UnknownSubstrateDetails Ziprasidone Cytochrome P450 3A4 Protein Humans UnknownSubstrateDetails - Drug Interactions
Drugs Interaction Integrate drug-drug
interactions in your softwareAlmotriptanClozapine The serum concentration of Almotriptan can be increased when it is combined with Clozapine. AlogliptinClozapine The serum concentration of Alogliptin can be increased when it is combined with Clozapine. AminophenazoneClozapine The serum concentration of Aminophenazone can be increased when it is combined with Clozapine. AmphetamineClozapine The serum concentration of Amphetamine can be increased when it is combined with Clozapine. AntipyrineClozapine The serum concentration of Antipyrine can be increased when it is combined with Clozapine.