Liver enzyme induction and inhibition: implications for anaesthesia.

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Sweeney BP, Bromilow J

Liver enzyme induction and inhibition: implications for anaesthesia.

Anaesthesia. 2006 Feb;61(2):159-77. doi: 10.1111/j.1365-2044.2005.04462.x.

PubMed ID

16430569 [ View in PubMed

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Abstract

Recent breakthroughs in molecular biology have enabled a reclassification of drug metabolising enzymes based on their amino acid sequence. This has led to a better understanding of drug metabolism and drug interactions. The majority of these drug metabolising enzymes may be either induced or inhibited by drugs or by extraneous substances including foodstuffs, cigarette smoke and environmental pollutants. Virtually all drugs used in anaesthesia are metabolised by either hepatic phase 1 or phase II enzymes. This review considers the classification of drug metabolising enzymes, explains the mechanisms of enzyme induction and inhibition, and also considers how the action of drugs commonly used by anaesthetists, including opioids and neuromuscular blocking drugs, may be altered by this mechanism.

DrugBank Data that Cites this Article

Drug Enzymes

Drug	Enzyme	Kind	Organism	Pharmacological Action	Actions
Clotrimazole	Cytochrome P450 2C9	Protein	Humans	Unknown	Inhibitor	Details
Tioconazole	Cytochrome P450 2C19	Protein	Humans	Unknown	Inhibitor	Details