Effect of phenobarbital on hepatic CYP1A1 and CYP1A2 in the Ahr-null mouse.

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Zaher H, Yang TJ, Gelboin HV, Fernandez-Salguero P, Gonzalez FJ

Effect of phenobarbital on hepatic CYP1A1 and CYP1A2 in the Ahr-null mouse.

Biochem Pharmacol. 1998 Jan 15;55(2):235-8.

PubMed ID

9448747 [ View in PubMed

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Abstract

Studies have suggested that phenobarbital (PB) induces members of the CYP1A subfamily by both transcriptional and post-transcriptional mechanisms. Using the Ahr -/- mice, we examined the induction of CYP1A1 and CYP1A2 by PB. CYP1A2 mRNA and protein were induced by PB in the null mice, suggesting that CYP1A2 is regulated by PB by a mechanism independent of the aryl hydrocarbon receptor (AHR). In contrast, the regulation of CYP1A1 is highly dependent on the AHR.

DrugBank Data that Cites this Article

Drug Enzymes

Drug	Enzyme	Kind	Organism	Pharmacological Action	Actions
Secobarbital	Cytochrome P450 1A2	Protein	Humans	Unknown	Inducer	Details