Drug Interactions of Metformin Involving Drug Transporter Proteins.

Article Details

Citation

Pakkir Maideen NM, Jumale A, Balasubramaniam R

Drug Interactions of Metformin Involving Drug Transporter Proteins.

Adv Pharm Bull. 2017 Dec;7(4):501-505. doi: 10.15171/apb.2017.062. Epub 2017 Dec 31.

PubMed ID
29399540 [ View in PubMed
]
Abstract

Metformin is a most widely used medication all around the world to treat Type 2 diabetes mellitus. It is also found to be effective against various conditions including, Prediabetes, Gestational diabetes mellitus (GDM), Polycystic Ovarian Syndrome (PCOS), Obesity, Cancer, etc. It is a cationic drug and it depends Organic Cation Transporters (OCTs) and Multidrug and Toxin Extruders (MATEs) mostly for its pharmacokinetics movement. The probability of drug interaction increases with the number of concomitant medications. This article focuses the drug interactions of metformin and most of them are linked to the inhibition of OCTs and MATEs leading to increased plasma metformin concentrations and subsequent elevation of risk of Metformin Associated Lactic Acidosis (MALA). By identifying the drugs inhibiting OCTs and MATEs, the healthcare professionals can predict the drug interactions of metformin.

DrugBank Data that Cites this Article

Drug Transporters
DrugTransporterKindOrganismPharmacological ActionActions
MetforminMultidrug and toxin extrusion protein 1ProteinHumans
Unknown
Substrate
Details
MetforminSolute carrier family 22 member 1ProteinHumans
Unknown
Substrate
Details
MetforminSolute carrier family 22 member 3ProteinHumans
Unknown
Substrate
Details
Drug Interactions
DrugsInteraction
Metformin
Atenolol
The serum concentration of Metformin can be increased when it is combined with Atenolol.