Drug Interactions of Metformin Involving Drug Transporter Proteins.

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Pakkir Maideen NM, Jumale A, Balasubramaniam R

Drug Interactions of Metformin Involving Drug Transporter Proteins.

Adv Pharm Bull. 2017 Dec;7(4):501-505. doi: 10.15171/apb.2017.062. Epub 2017 Dec 31.

PubMed ID

29399540 [ View in PubMed

]

Abstract

Metformin is a most widely used medication all around the world to treat Type 2 diabetes mellitus. It is also found to be effective against various conditions including, Prediabetes, Gestational diabetes mellitus (GDM), Polycystic Ovarian Syndrome (PCOS), Obesity, Cancer, etc. It is a cationic drug and it depends Organic Cation Transporters (OCTs) and Multidrug and Toxin Extruders (MATEs) mostly for its pharmacokinetics movement. The probability of drug interaction increases with the number of concomitant medications. This article focuses the drug interactions of metformin and most of them are linked to the inhibition of OCTs and MATEs leading to increased plasma metformin concentrations and subsequent elevation of risk of Metformin Associated Lactic Acidosis (MALA). By identifying the drugs inhibiting OCTs and MATEs, the healthcare professionals can predict the drug interactions of metformin.

DrugBank Data that Cites this Article

Drug Transporters

Drug	Transporter	Kind	Organism	Pharmacological Action	Actions
Metformin	Multidrug and toxin extrusion protein 1	Protein	Humans	Unknown	Substrate	Details
Metformin	Solute carrier family 22 member 1	Protein	Humans	Unknown	Substrate	Details
Metformin	Solute carrier family 22 member 3	Protein	Humans	Unknown	Substrate	Details

Drug Interactions

Drugs	Interaction
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Metformin Atenolol	The serum concentration of Metformin can be increased when it is combined with Atenolol.

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