Low dosage of levomepromazine did not increase plasma concentrations of fluvoxamine.

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Yoshimura R, Ueda N, Nakamura J

Low dosage of levomepromazine did not increase plasma concentrations of fluvoxamine.

Int Clin Psychopharmacol. 2000 Jul;15(4):233-5.

PubMed ID

10954064 [ View in PubMed

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Abstract

The cytochrome enzyme P450 2D6 (CYP2D6) is thought to play a role in the human metabolism of fluvoxamine. Levomepromazine is a potent inhibitor of CYP2D6. We coadministered a low dosage of levomepromazine and fluvoxamine in 15 patients and found that the low dosage of levomepromazine was effective in counteracting the fluvoxamine-induced insomnia and did not increase plasma fluvoxamine levels. These results suggest that the inhibition of CYP2D6 by levomepromazine has little effect on fluvoxamine metabolism. Therefore, a low dosage of levomepromazine, used as a hypnotic agent, appears to be effective and safe when coadministered with fluvoxamine. Since this was a pilot study without a placebo control, a double-blind placebo-controlled study is needed to confirm our preliminary findings.

DrugBank Data that Cites this Article

Drug Enzymes

Drug	Enzyme	Kind	Organism	Pharmacological Action	Actions
Methotrimeprazine	Cytochrome P450 2D6	Protein	Humans	Unknown	Substrate Inhibitor	Details