Variation in CYP2A6 Activity and Personalized Medicine.
Article Details
- CitationCopy to clipboard
Tanner JA, Tyndale RF
Variation in CYP2A6 Activity and Personalized Medicine.
J Pers Med. 2017 Dec 1;7(4). pii: jpm7040018. doi: 10.3390/jpm7040018.
- PubMed ID
- 29194389 [ View in PubMed]
- Abstract
The cytochrome P450 2A6 (CYP2A6) enzyme metabolizes several clinically relevant substrates, including nicotine-the primary psychoactive component in cigarette smoke. The gene that encodes the CYP2A6 enzyme is highly polymorphic, resulting in extensive interindividual variation in CYP2A6 enzyme activity and the rate of metabolism of nicotine and other CYP2A6 substrates including cotinine, tegafur, letrozole, efavirenz, valproic acid, pilocarpine, artemisinin, artesunate, SM-12502, caffeine, and tyrosol. CYP2A6 expression and activity are also impacted by non-genetic factors, including induction or inhibition by pharmacological, endogenous, and dietary substances, as well as age-related changes, or interactions with other hepatic enzymes, co-enzymes, and co-factors. As variation in CYP2A6 activity is associated with smoking behavior, smoking cessation, tobacco-related lung cancer risk, and with altered metabolism and resulting clinical responses for several therapeutics, CYP2A6 expression and enzyme activity is an important clinical consideration. This review will discuss sources of variation in CYP2A6 enzyme activity, with a focus on the impact of CYP2A6 genetic variation on metabolism of the CYP2A6 substrates.
DrugBank Data that Cites this Article
- Drug Enzymes
Drug Enzyme Kind Organism Pharmacological Action Actions Selegiline Cytochrome P450 2A6 Protein Humans UnknownSubstrateInhibitorDetails - Drug Interactions
Drugs Interaction Integrate drug-drug
interactions in your softwareAcetaminophenLetrozole The metabolism of Acetaminophen can be decreased when combined with Letrozole. AcetaminophenSeratrodast The metabolism of Acetaminophen can be decreased when combined with Seratrodast. AcetaminophenHydrocortisone The metabolism of Acetaminophen can be increased when combined with Hydrocortisone. AcetaminophenEletriptan The metabolism of Acetaminophen can be increased when combined with Eletriptan. AcetaminophenPrednisolone phosphate The metabolism of Acetaminophen can be increased when combined with Prednisolone phosphate.