The effect of trans sodium crocetinate (TSC) in a rat oleic acid model of acute lung injury.

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Gainer JL, Stennett AK, Murray RJ

The effect of trans sodium crocetinate (TSC) in a rat oleic acid model of acute lung injury.

Pulm Pharmacol Ther. 2005;18(3):213-6. Epub 2005 Jan 22.

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15707856 [ View in PubMed
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Abstract

Trans sodium crocetinate is a novel drug, which has been shown previously to increase whole-body oxygen consumption during hemorrhagic shock. TSC has been suggested to work by increasing the diffusion rate of oxygen through plasma rather than on a specific symptom of hemorrhagic shock and has been suggested as a general treatment for hypoxemia. Thus, it might also be beneficial for treating respiratory insufficiencies. This study employed an oleic acid model of acute lung injury to determine if TSC could increase arterial PO2 in that model.

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