Required propofol dose for anesthesia and time to emerge are affected by the use of antiepileptics: prospective cohort study.

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Citation

Ouchi K, Sugiyama K

Required propofol dose for anesthesia and time to emerge are affected by the use of antiepileptics: prospective cohort study.

BMC Anesthesiol. 2015 Mar 15;15:34. doi: 10.1186/s12871-015-0006-z. eCollection 2015.

PubMed ID
25788855 [ View in PubMed
]
Abstract

BACKGROUND: We investigated the impact of the type of neurological disorder on the required propofol dose for anesthesia and the time to emerge from anesthesia during dental treatment in patients with autism (AU), cerebral palsy (CP), and intellectual disability (ID), some of whom also had epilepsy. METHODS: We studied 224 patients with a neurological disorder who underwent dental treatment under intravenous general anesthesia. Patients were categorized according to neurological disorder (AU, CP, and ID; and with or without an antiepileptic). The propofol dose required for anesthesia, time to emerge, and modeled propofol blood concentration at emergence were evaluated. RESULTS: In patients not given an antiepileptic, we found no significant differences in the propofol dose, modeled propofol blood concentration at emergence, or time to emerge among patients with AU, CP, and ID (P > 0.05). When using an antiepileptic, the dose of propofol (5.7 +/- 1.51 mg/kg/h) was significantly lower than without an antiepileptic (6.8 +/- 1.27 mg/kg/h) (P < 0.0001). The modeled propofol blood concentration at emergence in patients given an antiepileptic (0.5 +/- 0.03 mug/ml) was significantly lower than without an antiepileptic (0.7 +/- 0.02 mug/ml) (P < 0.0001). The time to emerge in patients given an antiepileptic (29.5 +/- 12.5 min) was significantly longer than without an antiepileptic (21.6 min +/- 10.0 min) (P < 0.0001). CONCLUSION: The propofol dose required for anesthesia and the time to emerge from anesthesia are not affected by the type of neurological disorder, but are affected by antiepileptic use. TRIAL REGISTRATION: University Hospital Medical Information Network Clinical Trials Registry (UMIN000014179), Date of registration 4 June 2014.

DrugBank Data that Cites this Article

Drug Enzymes
DrugEnzymeKindOrganismPharmacological ActionActions
PropofolCytochrome P450 2C19ProteinHumans
Unknown
Substrate
Details
PropofolCytochrome P450 2C9ProteinHumans
Unknown
Substrate
Details