Isoniazid metabolism and hepatotoxicity.
Article Details
- CitationCopy to clipboard
Wang P, Pradhan K, Zhong XB, Ma X
Isoniazid metabolism and hepatotoxicity.
Acta Pharm Sin B. 2016 Sep;6(5):384-392. doi: 10.1016/j.apsb.2016.07.014. Epub 2016 Aug 3.
- PubMed ID
- 27709007 [ View in PubMed]
- Abstract
Isoniazid (INH) is highly effective for the management of tuberculosis. However, it can cause liver injury and even liver failure. INH metabolism has been thought to be associated with INH-induced liver injury. This review summarized the metabolic pathways of INH and discussed their associations with INH-induced liver injury.
DrugBank Data that Cites this Article
- Drug Enzymes
Drug Enzyme Kind Organism Pharmacological Action Actions Isoniazid Cytochrome P450 2E1 Protein Humans UnknownSubstrateInhibitorInducerDetails - Drug Interactions
Drugs Interaction Integrate drug-drug
interactions in your softwareIsoniazidDisulfiram The risk or severity of adverse effects can be increased when Disulfiram is combined with Isoniazid.