Omadacycline Enters the Ring: A New Antimicrobial Contender.
Article Details
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Barber KE, Bell AM, Wingler MJB, Wagner JL, Stover KR
Omadacycline Enters the Ring: A New Antimicrobial Contender.
Pharmacotherapy. 2018 Oct 5. doi: 10.1002/phar.2185.
- PubMed ID
- 30290000 [ View in PubMed]
- Abstract
Omadacycline is a novel aminomethylcycline seeking approval for treatment of community-acquired bacterial pneumonia and acute bacterial skin and skin structure infections. This article reviews existing data pertaining to the biochemistry, mechanism of action, pharmacokinetics/pharmacodynamics, in vitro activity, and current progress with omadacycline in clinical trials. Omadacycline inhibits protein synthesis by binding to the 30S subunit of the bacterial ribosome at the tetracycline binding site with an affinity similar to glycylcyclines. It is able to bypass older tetracycline resistance mechanisms and demonstrates activity against bacterial strains that are tetracycline resistant. Additionally, omadacycline displays broad-spectrum activity against gram-positive organisms (including methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci), gram-negative organisms, atypical organisms, and anaerobes. It has been evaluated against infections in adults both intravenously and orally. Dosage adjustments are not required for patients with renal impairment. Omadacycline displays a comparable efficacy and safety profile to standard-of-care agents, with the most common side effects observed being gastrointestinal. Currently available data for omadacycline suggest that this will be a promising agent to add to our antimicrobial armamentarium. This article is protected by copyright. All rights reserved.
DrugBank Data that Cites this Article
- Drugs
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Omadacycline 16S ribosomal RNA Nucleotide Enteric bacteria and other eubacteria YesInhibitorDetails Omadacycline 30S ribosomal protein S14 Protein Escherichia coli (strain K12) YesInhibitorDetails Omadacycline 30S ribosomal protein S19 Protein Escherichia coli (strain K12) YesInhibitorDetails Omadacycline 30S ribosomal protein S3 Protein Escherichia coli (strain K12) YesInhibitorDetails Omadacycline 30S ribosomal protein S7 Protein Escherichia coli (strain K12) YesInhibitorDetails Omadacycline 30S ribosomal protein S8 Protein Escherichia coli (strain K12) YesInhibitorDetails