A Comprehensive Review of Drug-Drug Interactions with Metformin.
Article Details
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Stage TB, Brosen K, Christensen MM
A Comprehensive Review of Drug-Drug Interactions with Metformin.
Clin Pharmacokinet. 2015 Aug;54(8):811-24. doi: 10.1007/s40262-015-0270-6.
- PubMed ID
- 25943187 [ View in PubMed]
- Abstract
Metformin is the world's most commonly used oral glucose-lowering drug for type 2 diabetes, and this is mainly because it protects against diabetes-related mortality and all-cause mortality. Although it is an old drug, its mechanism of action has not yet been clarified and its pharmacokinetic pathway is still not fully understood. There is considerable inter-individual variability in the response to metformin, and this has led to many drug-drug interaction (DDI) studies of metformin. In this review, we describe both in vitro and human interaction studies of metformin both as a victim and as a perpetrator. We also clarify the importance of including pharmacodynamic end points in DDI studies of metformin and taking pharmacogenetic variation into account when performing these studies to avoid hidden pitfalls in the interpretation of DDIs with metformin. This evaluation of the literature has revealed holes in our knowledge and given clues as to where future DDI studies should be focused and performed.
DrugBank Data that Cites this Article
- Drug Transporters
Drug Transporter Kind Organism Pharmacological Action Actions Clopidogrel Solute carrier family 22 member 1 Protein Humans NoInhibitorDetails Doxazosin Solute carrier family 22 member 1 Protein Humans NoInhibitorDetails - Drug Interactions
Drugs Interaction Integrate drug-drug
interactions in your softwareAcetylcholineCholine The risk or severity of adverse effects can be increased when Choline is combined with Acetylcholine. AcetylcholineNicotine The risk or severity of adverse effects can be increased when Nicotine is combined with Acetylcholine. AcetylcholineReserpine The risk or severity of adverse effects can be increased when Reserpine is combined with Acetylcholine. AcetylcholineNelfinavir The risk or severity of adverse effects can be increased when Nelfinavir is combined with Acetylcholine. AcetylcholineIndinavir The risk or severity of adverse effects can be increased when Indinavir is combined with Acetylcholine.