A Comprehensive Review of Drug-Drug Interactions with Metformin.

Article Details

Citation

Stage TB, Brosen K, Christensen MM

A Comprehensive Review of Drug-Drug Interactions with Metformin.

Clin Pharmacokinet. 2015 Aug;54(8):811-24. doi: 10.1007/s40262-015-0270-6.

PubMed ID
25943187 [ View in PubMed
]
Abstract

Metformin is the world's most commonly used oral glucose-lowering drug for type 2 diabetes, and this is mainly because it protects against diabetes-related mortality and all-cause mortality. Although it is an old drug, its mechanism of action has not yet been clarified and its pharmacokinetic pathway is still not fully understood. There is considerable inter-individual variability in the response to metformin, and this has led to many drug-drug interaction (DDI) studies of metformin. In this review, we describe both in vitro and human interaction studies of metformin both as a victim and as a perpetrator. We also clarify the importance of including pharmacodynamic end points in DDI studies of metformin and taking pharmacogenetic variation into account when performing these studies to avoid hidden pitfalls in the interpretation of DDIs with metformin. This evaluation of the literature has revealed holes in our knowledge and given clues as to where future DDI studies should be focused and performed.

DrugBank Data that Cites this Article

Drug Transporters
DrugTransporterKindOrganismPharmacological ActionActions
ClopidogrelSolute carrier family 22 member 1ProteinHumans
No
Inhibitor
Details
DoxazosinSolute carrier family 22 member 1ProteinHumans
No
Inhibitor
Details
Drug Interactions
DrugsInteraction
Acetylcholine
Choline
The risk or severity of adverse effects can be increased when Choline is combined with Acetylcholine.
Acetylcholine
Nicotine
The risk or severity of adverse effects can be increased when Nicotine is combined with Acetylcholine.
Acetylcholine
Reserpine
The risk or severity of adverse effects can be increased when Reserpine is combined with Acetylcholine.
Acetylcholine
Nelfinavir
The risk or severity of adverse effects can be increased when Nelfinavir is combined with Acetylcholine.
Acetylcholine
Indinavir
The risk or severity of adverse effects can be increased when Indinavir is combined with Acetylcholine.