MATE1 regulates cellular uptake and sensitivity to imatinib in CML patients.

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Harrach S, Schmidt-Lauber C, Pap T, Pavenstadt H, Schlatter E, Schmidt E, Berdel WE, Schulze U, Edemir B, Jeromin S, Haferlach T, Ciarimboli G, Bertrand J

MATE1 regulates cellular uptake and sensitivity to imatinib in CML patients.

Blood Cancer J. 2016 Sep 16;6:e470. doi: 10.1038/bcj.2016.79.

PubMed ID

27635733 [ View in PubMed

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Abstract

Although imatinib is highly effective in the treatment of chronic myeloid leukemia (CML), 25-30% patients do not respond or relapse after initial response. Imatinib uptake into targeted cells is crucial for its molecular response and clinical effectiveness. The organic cation transporter 1 (OCT1) has been proposed to be responsible for this process, but its relevance has been discussed controversially in recent times. Here we found that the multidrug and toxin extrusion protein 1 (MATE1) transports imatinib with a manifold higher affinity. MATE1 mainly mediates the cellular uptake of imatinib into targeted cells and thereby controls the intracellular effectiveness of imatinib. Importantly, MATE1 but not OCT1 expression is reduced in total bone marrow cells of imatinib-non-responding CML patients compared with imatinib-responding patients, indicating that MATE1 but not OCT1 determines the therapeutic success of imatinib. We thus propose that imatinib non-responders could be identified early before starting therapy by measuring MATE1 expression levels.

DrugBank Data that Cites this Article

Drug Transporters

Drug	Transporter	Kind	Organism	Pharmacological Action	Actions
Amantadine	Solute carrier family 22 member 1	Protein	Humans	Unknown	Substrate Inhibitor	Details