The major metabolite of bendazac inhibits the glycosylation of soluble lens proteins: a possible mechanism for a delay in cataractogenesis.
Article Details
- CitationCopy to clipboard
Lewis BS, Harding JJ
The major metabolite of bendazac inhibits the glycosylation of soluble lens proteins: a possible mechanism for a delay in cataractogenesis.
Exp Eye Res. 1988 Aug;47(2):217-25.
- PubMed ID
- 3409993 [ View in PubMed]
- Abstract
Glucose-6-phosphate and galactose react non-enzymically with lens proteins. The rates of these reactions are decreased by 5-hydroxybendazac but not by its parent compound, bendazac. Both bendazac and its major metabolite bind to lens proteins, mostly by non-covalent interactions. These results are discussed in relation to the use of bendazac as an anti-cataract drug.
DrugBank Data that Cites this Article
- Drugs
- Drug Reactions
Reaction Details
