Pharmacogenomics of CYP3A: considerations for HIV treatment.
Article Details
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Lakhman SS, Ma Q, Morse GD
Pharmacogenomics of CYP3A: considerations for HIV treatment.
Pharmacogenomics. 2009 Aug;10(8):1323-39. doi: 10.2217/pgs.09.53.
- PubMed ID
- 19663676 [ View in PubMed]
- Abstract
The understanding of the cytochrome P450 3A SNP in antiretroviral therapy is important, because it is highly inducible, extremely polymorphic and metabolizes many of the drugs that are key components of highly active antiretroviral therapy regimens. This enzyme is prolific and promiscuous towards drug and xenobiotic substrate selection and it is also unpredictable among individuals, having a 5- to 20-fold variability in its ability to contribute to drug clearance. The importance of human CYP3A pharmacogenetics is also gaining attention in other established areas of pharmacotherapy as it may contribute to the goal of predicting efficacy and/or toxicity, specifically with the discovery of null allele CYP3A4*20. This review summarizes the current understanding, implications of genetic variation in the CYP3A enzymes, the central role of CYP3A in linking human genetics, the pharmacokinetics and resulting pharmacodynamic responses to certain antiretroviral drugs, and their eventual place in applied clinical pharmacotherapy.
DrugBank Data that Cites this Article
- Drug Enzymes
Drug Enzyme Kind Organism Pharmacological Action Actions Efavirenz Cytochrome P450 3A4 Protein Humans UnknownSubstrateInhibitorInducerDetails