Sugammadex: A revolutionary drug in neuromuscular pharmacology.

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Nag K, Singh DR, Shetti AN, Kumar H, Sivashanmugam T, Parthasarathy S

Sugammadex: A revolutionary drug in neuromuscular pharmacology.

Anesth Essays Res. 2013 Sep-Dec;7(3):302-6. doi: 10.4103/0259-1162.123211.

PubMed ID

25885973 [ View in PubMed

]

Abstract

Sugammadex (ORG 25969) is a unique neuromuscular reversal drug; a novel cyclodextrin, the first in a new class of selective relaxant binding agents, which reverse neuromuscular blockade (NMB) with the aminosteroid non-depolarizing muscle relaxants rocuronium and vecuronium. Sugammadex can reverse moderate or deep NMB. The clinical use of sugammadex promises to eliminate many of the shortcomings in current anesthetic practice with regard to antagonism of rocuronium and other aminosteroid muscle relaxants.

DrugBank Data that Cites this Article

Drugs

Sugammadex

Drug Interactions

Drugs	Interaction
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Sugammadex Toremifene	The therapeutic efficacy of Sugammadex can be decreased when used in combination with Toremifene.