Structures of the bacterial ribosome at 3.5 A resolution.

Article Details


Schuwirth BS, Borovinskaya MA, Hau CW, Zhang W, Vila-Sanjurjo A, Holton JM, Cate JH

Structures of the bacterial ribosome at 3.5 A resolution.

Science. 2005 Nov 4;310(5749):827-34.

PubMed ID
16272117 [ View in PubMed

We describe two structures of the intact bacterial ribosome from Escherichia coli determined to a resolution of 3.5 angstroms by x-ray crystallography. These structures provide a detailed view of the interface between the small and large ribosomal subunits and the conformation of the peptidyl transferase center in the context of the intact ribosome. Differences between the two ribosomes reveal a high degree of flexibility between the head and the rest of the small subunit. Swiveling of the head of the small subunit observed in the present structures, coupled to the ratchet-like motion of the two subunits observed previously, suggests a mechanism for the final movements of messenger RNA (mRNA) and transfer RNAs (tRNAs) during translocation.

DrugBank Data that Cites this Article

NameUniProt ID
30S ribosomal protein S4P0A7V8Details
30S ribosomal protein S9P0A7X3Details
30S ribosomal protein S10P0A7R5Details
30S ribosomal protein S12P0A7S3Details
50S ribosomal protein L4P60723Details
30S ribosomal protein S14P0AG59Details
30S ribosomal protein S13P0A7S9Details
30S ribosomal protein S19P0A7U3Details
50S ribosomal protein L16P0ADY7Details
30S ribosomal protein S3P0A7V3Details
30S ribosomal protein S8P0A7W7Details
30S ribosomal protein S7P02359Details