The diploid genome sequence of Candida albicans.

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Jones T, Federspiel NA, Chibana H, Dungan J, Kalman S, Magee BB, Newport G, Thorstenson YR, Agabian N, Magee PT, Davis RW, Scherer S

The diploid genome sequence of Candida albicans.

Proc Natl Acad Sci U S A. 2004 May 11;101(19):7329-34. Epub 2004 May 3.

PubMed ID
15123810 [ View in PubMed
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Abstract

We present the diploid genome sequence of the fungal pathogen Candida albicans. Because C. albicans has no known haploid or homozygous form, sequencing was performed as a whole-genome shotgun of the heterozygous diploid genome in strain SC5314, a clinical isolate that is the parent of strains widely used for molecular analysis. We developed computational methods to assemble a diploid genome sequence in good agreement with available physical mapping data. We provide a whole-genome description of heterozygosity in the organism. Comparative genomic analyses provide important clues about the evolution of the species and its mechanisms of pathogenesis.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
Thymidylate synthaseP12461Details
Lanosterol 14-alpha demethylaseP10613Details
Glucan 1,3-beta-glucosidaseP29717Details
Glycylpeptide N-tetradecanoyltransferaseP30418Details
Lanosterol synthaseQ04782Details
Squalene monooxygenaseQ92206Details
Candidapepsin-2P0DJ06Details
Inositol phosphorylceramide synthaseO13332Details