Signal transduction by vascular endothelial growth factor receptors.

Article Details

Citation

Koch S, Tugues S, Li X, Gualandi L, Claesson-Welsh L

Signal transduction by vascular endothelial growth factor receptors.

Biochem J. 2011 Jul 15;437(2):169-83. doi: 10.1042/BJ20110301.

PubMed ID
21711246 [ View in PubMed
]
Abstract

VEGFs (vascular endothelial growth factors) control vascular development during embryogenesis and the function of blood vessels and lymphatic vessels in the adult. There are five related mammalian ligands, which act through three receptor tyrosine kinases. Signalling is modulated through neuropilins, which act as VEGF co-receptors. Heparan sulfate and integrins are also important modulators of VEGF signalling. Therapeutic agents that interfere with VEGF signalling have been developed with the aim of decreasing angiogenesis in diseases that involve tissue growth and inflammation, such as cancer. The present review will outline the current understanding and consequent biology of VEGF receptor signalling.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
Vascular endothelial growth factor receptor 3P35916Details
Vascular endothelial growth factor receptor 1P17948Details
Vascular endothelial growth factor receptor 2P35968Details