Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q.

Article Details


Loftus BJ, Kim UJ, Sneddon VP, Kalush F, Brandon R, Fuhrmann J, Mason T, Crosby ML, Barnstead M, Cronin L, Deslattes Mays A, Cao Y, Xu RX, Kang HL, Mitchell S, Eichler EE, Harris PC, Venter JC, Adams MD

Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q.

Genomics. 1999 Sep 15;60(3):295-308.

PubMed ID
10493829 [ View in PubMed

Several publicly funded large-scale sequencing efforts have been initiated with the goal of completing the first reference human genome sequence by the year 2005. Here we present the results of analysis of 11.8 Mb of genomic sequence from chromosome 16. The apparent gene density varies throughout the region, but the number of genes predicted (84) suggests that this is a gene-poor region. This result may also suggest that the total number of human genes is likely to be at the lower end of published estimates. One of the most interesting aspects of this region of the genome is the presence of highly homologous, recently duplicated tracts of sequence distributed throughout the p-arm. Such duplications have implications for mapping and gene analysis as well as the predisposition to recurrent chromosomal structural rearrangements associated with genetic disease.

DrugBank Data that Cites this Article

NameUniProt ID
Amiloride-sensitive sodium channel subunit betaP51168Details
Ketimine reductase mu-crystallinQ14894Details
NEDD8-activating enzyme E1 regulatory subunitQ13564Details
Integrin alpha-LP20701Details
Acyl carrier protein, mitochondrialO14561Details
Multidrug resistance-associated protein 1P33527Details
Protein kinase C beta typeP05771Details
Interleukin-4 receptor subunit alphaP24394Details
Carbonic anhydrase 7P43166Details
Multidrug resistance-associated protein 6O95255Details
Eukaryotic peptide chain release factor GTP-binding subunit ERF3AP15170Details
Haptoglobin-related proteinP00739Details
Voltage-dependent calcium channel gamma-3 subunitO60359Details
Tumor necrosis factor receptor superfamily member 17Q02223Details