Changes of glucose metabolism and skin-collagen neogenesis in vitamin B6 deficiency.

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Inubushi T, Takasawa T, Tuboi Y, Watanabe N, Aki K, Katunuma N

Changes of glucose metabolism and skin-collagen neogenesis in vitamin B6 deficiency.

Biofactors. 2005;23(2):59-67.

PubMed ID

16179747 [ View in PubMed

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Abstract

The mechanism of pellagrous changes in skin caused by a deficiency of vitamin B6 was studied in respect to neogenesis of proline in skin collagen and glucose metabolism. In vitamin B6 deficiency the insulin/glucagon coefficient in serum decreased significantly from 3.02 to 2.32, indicating a metabolic change towards gluconeogenesis. A deficiency of vitamin B6 caused a decrease in the levels of vitamin B6-dependent enzymes, such as ornithine aminotransferase, alanine aminotransferase, and aspartate aminotransferase, which also contribute to gluconeogenesis. Because the conversion of ornithine to proline via pyrroline-5-carboxylate was suppressed due to the decrease in ornithine aminotransferase activity, the amount of proline in the skin collagen fraction also decreased significantly in vitamin B6-deficient rats compared with the pair-fed control. These results suggest that the pellagrous lesions in vitamin B6-deficiency are caused by an impaired synthesis of proline from ornithine, which results in the suppression of collagen neogenesis in the skin.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Ornithine	Ornithine aminotransferase, mitochondrial	Protein	Humans	Unknown	Not Available	Details
Pyridoxal phosphate	Alanine aminotransferase 1	Protein	Humans	Unknown	Cofactor	Details