The DNA sequence and analysis of human chromosome 13.

Article Details

Citation

Dunham A, Matthews LH, Burton J, Ashurst JL, Howe KL, Ashcroft KJ, Beare DM, Burford DC, Hunt SE, Griffiths-Jones S, Jones MC, Keenan SJ, Oliver K, Scott CE, Ainscough R, Almeida JP, Ambrose KD, Andrews DT, Ashwell RI, Babbage AK, Bagguley CL, Bailey J, Bannerjee R, Barlow KF, Bates K, Beasley H, Bird CP, Bray-Allen S, Brown AJ, Brown JY, Burrill W, Carder C, Carter NP, Chapman JC, Clamp ME, Clark SY, Clarke G, Clee CM, Clegg SC, Cobley V, Collins JE, Corby N, Coville GJ, Deloukas P, Dhami P, Dunham I, Dunn M, Earthrowl ME, Ellington AG, Faulkner L, Frankish AG, Frankland J, French L, Garner P, Garnett J, Gilbert JG, Gilson CJ, Ghori J, Grafham DV, Gribble SM, Griffiths C, Hall RE, Hammond S, Harley JL, Hart EA, Heath PD, Howden PJ, Huckle EJ, Hunt PJ, Hunt AR, Johnson C, Johnson D, Kay M, Kimberley AM, King A, Laird GK, Langford CJ, Lawlor S, Leongamornlert DA, Lloyd DM, Lloyd C, Loveland JE, Lovell J, Martin S, Mashreghi-Mohammadi M, McLaren SJ, McMurray A, Milne S, Moore MJ, Nickerson T, Palmer SA, Pearce AV, Peck AI, Pelan S, Phillimore B, Porter KM, Rice CM, Searle S, Sehra HK, Shownkeen R, Skuce CD, Smith M, Steward CA, Sycamore N, Tester J, Thomas DW, Tracey A, Tromans A, Tubby B, Wall M, Wallis JM, West AP, Whitehead SL, Willey DL, Wilming L, Wray PW, Wright MW, Young L, Coulson A, Durbin R, Hubbard T, Sulston JE, Beck S, Bentley DR, Rogers J, Ross MT

The DNA sequence and analysis of human chromosome 13.

Nature. 2004 Apr 1;428(6982):522-8.

PubMed ID
15057823 [ View in PubMed
]
Abstract

Chromosome 13 is the largest acrocentric human chromosome. It carries genes involved in cancer including the breast cancer type 2 (BRCA2) and retinoblastoma (RB1) genes, is frequently rearranged in B-cell chronic lymphocytic leukaemia, and contains the DAOA locus associated with bipolar disorder and schizophrenia. We describe completion and analysis of 95.5 megabases (Mb) of sequence from chromosome 13, which contains 633 genes and 296 pseudogenes. We estimate that more than 95.4% of the protein-coding genes of this chromosome have been identified, on the basis of comparison with other vertebrate genome sequences. Additionally, 105 putative non-coding RNA genes were found. Chromosome 13 has one of the lowest gene densities (6.5 genes per Mb) among human chromosomes, and contains a central region of 38 Mb where the gene density drops to only 3.1 genes per Mb.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
Vascular endothelial growth factor receptor 1P17948Details
Endothelin B receptorP24530Details
Cysteinyl leukotriene receptor 2Q9NS75Details
Receptor-type tyrosine-protein kinase FLT3P36888Details
Mitochondrial ornithine transporter 1Q9Y619Details
High affinity cationic amino acid transporter 1P30825Details
Coagulation factor VIIP08709Details
5-hydroxytryptamine receptor 2AP28223Details
Propionyl-CoA carboxylase alpha chain, mitochondrialP05165Details
Vitamin K-dependent protein ZP22891Details
Potassium-transporting ATPase subunit betaP51164Details
Tumor necrosis factor ligand superfamily member 13BQ9Y275Details
Solute carrier family 15 member 1P46059Details
E3 ubiquitin-protein ligase TRIM13O60858Details
Multidrug resistance-associated protein 4O15439Details
Tubulin alpha-3C/D chainQ13748Details
Ras-related protein Rap-2aP10114Details
Retinoblastoma-associated proteinP06400Details
Cyclin-dependent kinase 8P49336Details
Succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrialQ9P2R7Details
S-formylglutathione hydrolaseP10768Details
N-arachidonyl glycine receptorQ14330Details
Probable cysteine--tRNA ligase, mitochondrialQ9HA77Details
Arachidonate 5-lipoxygenase-activating proteinP20292Details
Carboxypeptidase B2Q96IY4Details
High mobility group protein B1P09429Details
Motilin receptorO43193Details
Ileal sodium/bile acid cotransporterQ12908Details
Copper-transporting ATPase 2P35670Details
Gamma-glutamylaminecyclotransferaseQ9BVM4Details
Translationally-controlled tumor proteinP13693Details
Heat shock protein 105 kDaQ92598Details
G-protein coupled receptor 12P47775Details
Serine/threonine-protein kinase 24Q9Y6E0Details
Serine/threonine-protein kinase DCLK1O15075Details
Serine/threonine-protein kinase Nek3P51956Details
Serine/threonine-protein kinase Nek5Q6P3R8Details
Nucleotide triphosphate diphosphatase NUDT15Q9NV35Details
Lysophosphatidic acid receptor 6P43657Details
Diacylglycerol kinase etaQ86XP1Details
Potassium-transporting ATPase alpha chain 2P54707Details