The DNA sequence and analysis of human chromosome 13.
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Dunham A, Matthews LH, Burton J, Ashurst JL, Howe KL, Ashcroft KJ, Beare DM, Burford DC, Hunt SE, Griffiths-Jones S, Jones MC, Keenan SJ, Oliver K, Scott CE, Ainscough R, Almeida JP, Ambrose KD, Andrews DT, Ashwell RI, Babbage AK, Bagguley CL, Bailey J, Bannerjee R, Barlow KF, Bates K, Beasley H, Bird CP, Bray-Allen S, Brown AJ, Brown JY, Burrill W, Carder C, Carter NP, Chapman JC, Clamp ME, Clark SY, Clarke G, Clee CM, Clegg SC, Cobley V, Collins JE, Corby N, Coville GJ, Deloukas P, Dhami P, Dunham I, Dunn M, Earthrowl ME, Ellington AG, Faulkner L, Frankish AG, Frankland J, French L, Garner P, Garnett J, Gilbert JG, Gilson CJ, Ghori J, Grafham DV, Gribble SM, Griffiths C, Hall RE, Hammond S, Harley JL, Hart EA, Heath PD, Howden PJ, Huckle EJ, Hunt PJ, Hunt AR, Johnson C, Johnson D, Kay M, Kimberley AM, King A, Laird GK, Langford CJ, Lawlor S, Leongamornlert DA, Lloyd DM, Lloyd C, Loveland JE, Lovell J, Martin S, Mashreghi-Mohammadi M, McLaren SJ, McMurray A, Milne S, Moore MJ, Nickerson T, Palmer SA, Pearce AV, Peck AI, Pelan S, Phillimore B, Porter KM, Rice CM, Searle S, Sehra HK, Shownkeen R, Skuce CD, Smith M, Steward CA, Sycamore N, Tester J, Thomas DW, Tracey A, Tromans A, Tubby B, Wall M, Wallis JM, West AP, Whitehead SL, Willey DL, Wilming L, Wray PW, Wright MW, Young L, Coulson A, Durbin R, Hubbard T, Sulston JE, Beck S, Bentley DR, Rogers J, Ross MT
The DNA sequence and analysis of human chromosome 13.
Nature. 2004 Apr 1;428(6982):522-8.
- PubMed ID
- 15057823 [ View in PubMed]
- Abstract
Chromosome 13 is the largest acrocentric human chromosome. It carries genes involved in cancer including the breast cancer type 2 (BRCA2) and retinoblastoma (RB1) genes, is frequently rearranged in B-cell chronic lymphocytic leukaemia, and contains the DAOA locus associated with bipolar disorder and schizophrenia. We describe completion and analysis of 95.5 megabases (Mb) of sequence from chromosome 13, which contains 633 genes and 296 pseudogenes. We estimate that more than 95.4% of the protein-coding genes of this chromosome have been identified, on the basis of comparison with other vertebrate genome sequences. Additionally, 105 putative non-coding RNA genes were found. Chromosome 13 has one of the lowest gene densities (6.5 genes per Mb) among human chromosomes, and contains a central region of 38 Mb where the gene density drops to only 3.1 genes per Mb.
DrugBank Data that Cites this Article
- Polypeptides
Name UniProt ID Vascular endothelial growth factor receptor 1 P17948 Details Endothelin B receptor P24530 Details Cysteinyl leukotriene receptor 2 Q9NS75 Details Receptor-type tyrosine-protein kinase FLT3 P36888 Details Mitochondrial ornithine transporter 1 Q9Y619 Details High affinity cationic amino acid transporter 1 P30825 Details Coagulation factor VII P08709 Details 5-hydroxytryptamine receptor 2A P28223 Details Propionyl-CoA carboxylase alpha chain, mitochondrial P05165 Details Vitamin K-dependent protein Z P22891 Details Potassium-transporting ATPase subunit beta P51164 Details Tumor necrosis factor ligand superfamily member 13B Q9Y275 Details Solute carrier family 15 member 1 P46059 Details E3 ubiquitin-protein ligase TRIM13 O60858 Details Multidrug resistance-associated protein 4 O15439 Details Tubulin alpha-3C/D chain Q13748 Details Ras-related protein Rap-2a P10114 Details Retinoblastoma-associated protein P06400 Details Cyclin-dependent kinase 8 P49336 Details Succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial Q9P2R7 Details S-formylglutathione hydrolase P10768 Details N-arachidonyl glycine receptor Q14330 Details Probable cysteine--tRNA ligase, mitochondrial Q9HA77 Details Arachidonate 5-lipoxygenase-activating protein P20292 Details Carboxypeptidase B2 Q96IY4 Details High mobility group protein B1 P09429 Details Motilin receptor O43193 Details Ileal sodium/bile acid cotransporter Q12908 Details Copper-transporting ATPase 2 P35670 Details Gamma-glutamylaminecyclotransferase Q9BVM4 Details Translationally-controlled tumor protein P13693 Details Heat shock protein 105 kDa Q92598 Details G-protein coupled receptor 12 P47775 Details Serine/threonine-protein kinase 24 Q9Y6E0 Details Serine/threonine-protein kinase DCLK1 O15075 Details Serine/threonine-protein kinase Nek3 P51956 Details Serine/threonine-protein kinase Nek5 Q6P3R8 Details Nucleotide triphosphate diphosphatase NUDT15 Q9NV35 Details Lysophosphatidic acid receptor 6 P43657 Details Diacylglycerol kinase eta Q86XP1 Details Potassium-transporting ATPase alpha chain 2 P54707 Details Collagen alpha-1(IV) chain P02462 Details