Alternative splicing of human insulin receptor messenger RNA.
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Seino S, Bell GI
Alternative splicing of human insulin receptor messenger RNA.
Biochem Biophys Res Commun. 1989 Feb 28;159(1):312-6.
- PubMed ID
- 2538124 [ View in PubMed]
- Abstract
The polymerase chain reaction has been used to examine alternative splicing of human insulin receptor (hINSR) mRNA. Alternative splicing of a 36 base pair exon, exon 11, generates hINSR transcripts encoding receptor isoforms which differ in sequence at the C-terminal end of the insulin-binding alpha-subunit. This process appears to be tissue-specific and, in addition, may be developmentally regulated.