Retinol dehydrogenase (RDH12) protects photoreceptors from light-induced degeneration in mice.

Article Details

Citation

Copy to clipboard

Maeda A, Maeda T, Imanishi Y, Sun W, Jastrzebska B, Hatala DA, Winkens HJ, Hofmann KP, Janssen JJ, Baehr W, Driessen CA, Palczewski K

Retinol dehydrogenase (RDH12) protects photoreceptors from light-induced degeneration in mice.

J Biol Chem. 2006 Dec 8;281(49):37697-704. Epub 2006 Oct 10.

PubMed ID

17032653 [ View in PubMed

]

Abstract

RDH12 has been suggested to be one of the retinol dehydrogenases (RDH) involved in the vitamin A recycling system (visual cycle) in the eye. Loss of function mutations in the RDH12 gene were recently reported to be associated with autosomal recessive childhood-onset severe retinal dystrophy. Here we show that RDH12 localizes to the photoreceptor inner segments and that deletion of this gene in mice slows the kinetics of all-trans-retinal reduction, delaying dark adaptation. However, accelerated 11-cis-retinal production and increased susceptibility to light-induced photoreceptor apoptosis were also observed in Rdh12(-/-) mice, suggesting that RDH12 plays a unique, nonredundant role in the photoreceptor inner segments to regulate the flow of retinoids in the eye. Thus, severe visual impairments of individuals with null mutations in RDH12 may likely be caused by light damage(1).

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Vitamin A	Retinol dehydrogenase 12	Protein	Humans	Unknown	Substrate	Details