RDH12, a retinol dehydrogenase causing Leber's congenital amaurosis, is also involved in steroid metabolism.
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Keller B, Adamski J
RDH12, a retinol dehydrogenase causing Leber's congenital amaurosis, is also involved in steroid metabolism.
J Steroid Biochem Mol Biol. 2007 May;104(3-5):190-4. Epub 2007 Mar 23.
- PubMed ID
- 17512723 [ View in PubMed]
- Abstract
Three retinol dehydrogenases (RDHs) were tested for steroid converting abilities: human and murine RDH 12 and human RDH13. RDH12 is involved in retinal degeneration in Leber's congenital amaurosis (LCA). We show that murine Rdh12 and human RDH13 do not reveal activity towards the checked steroids, but that human type 12 RDH reduces dihydrotestosterone to androstanediol, and is thus also involved in steroid metabolism. Furthermore, we analyzed both expression and subcellular localization of these enzymes.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Vitamin A Retinol dehydrogenase 12 Protein Humans UnknownSubstrateDetails Vitamin A Retinol dehydrogenase 13 Protein Humans UnknownSubstrateDetails