Crystal structure of the tyrosine kinase domain of the human insulin receptor.

Article Details

Citation

Hubbard SR, Wei L, Ellis L, Hendrickson WA

Crystal structure of the tyrosine kinase domain of the human insulin receptor.

Nature. 1994 Dec 22-29;372(6508):746-54.

PubMed ID
7997262 [ View in PubMed
]
Abstract

The X-ray crystal structure of the tyrosine kinase domain of the human insulin receptor has been determined by multiwavelength anomalous diffraction phasing and refined to 2.1 A resolution. The structure reveals the determinants of substrate preference for tyrosine rather than serine or threonine and a novel autoinhibition mechanism whereby one of the tyrosines that is autophosphorylated in response to insulin, Tyr 1,162, is bound in the active site.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
Insulin receptorP06213Details