Crystal structure of the tyrosine kinase domain of the human insulin receptor.
Article Details
- CitationCopy to clipboard
Hubbard SR, Wei L, Ellis L, Hendrickson WA
Crystal structure of the tyrosine kinase domain of the human insulin receptor.
Nature. 1994 Dec 22-29;372(6508):746-54.
- PubMed ID
- 7997262 [ View in PubMed]
- Abstract
The X-ray crystal structure of the tyrosine kinase domain of the human insulin receptor has been determined by multiwavelength anomalous diffraction phasing and refined to 2.1 A resolution. The structure reveals the determinants of substrate preference for tyrosine rather than serine or threonine and a novel autoinhibition mechanism whereby one of the tyrosines that is autophosphorylated in response to insulin, Tyr 1,162, is bound in the active site.