PPARgamma activators down-regulate the expression of PPARgamma in 3T3-L1 adipocytes.
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Camp HS, Whitton AL, Tafuri SR
PPARgamma activators down-regulate the expression of PPARgamma in 3T3-L1 adipocytes.
FEBS Lett. 1999 Mar 26;447(2-3):186-90.
- PubMed ID
- 10214942 [ View in PubMed]
- Abstract
Transcriptional activation of PPARgamma by the anti-diabetic compound troglitazone enhances the rate of 3T3-L1 adipocyte differentiation. In this study, we examined the effects of troglitazone, a specific PPARgamma ligand, on the expression of PPARgamma during and after 3T3-L1 adipocyte differentiation. Troglitazone treatment caused a significant decrease in PPARgamma proteins and DNA binding activity. This reduction was associated with a similar decrease in transcription of PPARgamma mRNA. These data suggest that in 3T3-L1 cells, the expression of PPARgamma is auto-regulated.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Troglitazone Peroxisome proliferator-activated receptor gamma Protein Humans YesAgonistRegulatorDetails