Prostaglandin J2 and its metabolites promote neurite outgrowth induced by nerve growth factor in PC12 cells.

Article Details

Citation

Copy to clipboard

Satoh T, Furuta K, Suzuki M, Watanabe Y

Prostaglandin J2 and its metabolites promote neurite outgrowth induced by nerve growth factor in PC12 cells.

Biochem Biophys Res Commun. 1999 Apr 29;258(1):50-3.

PubMed ID

10222233 [ View in PubMed

]

Abstract

Although A- and J-type prostaglandins (PG's) arrest the cell cycle at the G1 phase in vitro and suppress tumor growth in vivo, their effects on neuronal cells have not so far been clarified. Here, we found promotion of neurite outgrowth as a novel biological function of PGJ's. In PC12h cells, PGJ's (PGJ2, Delta12-PGJ2 and 15-deoxy-Delta12,14-PGJ2) promoted neurite outgrowth in the presence of nerve growth factor (NGF), whereas they themselves did not show such a promotion. The potency of promoting neurite outgrowth was PGJ2 < Delta12-PGJ2 < 15-deoxy-Delta12,14-PGJ2. However, troglitazone, an activator of peroxisome proliferator-activated receptorgamma (PPARgamma), and other PG's including PGA1, PGA2 and PGD2 did not promote neurite outgrowth. These results suggest that PGJ's promote neurite outgrowth independently of PPARgamma activation.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Troglitazone	Peroxisome proliferator-activated receptor gamma	Protein	Humans	Yes	Agonist Regulator	Details