Pharmacology and chemistry of adapalene.

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Shroot B, Michel S

Pharmacology and chemistry of adapalene.

J Am Acad Dermatol. 1997 Jun;36(6 Pt 2):S96-103.

PubMed ID
9204085 [ View in PubMed
]
Abstract

BACKGROUND: Retinoid research in the field of dermatology has been influenced by the clinical success of topical tretinoin and oral isotretinoin in the treatment of acne, and by the discovery of high-affinity binding proteins for retinoic acid mediating its action and interaction with other vitamins and hormones. OBJECTIVE: We sought molecules with an optimal balance between stability, efficacy, and local tolerance for topical acne therapy. METHODS: In vitro and in vivo bioassay systems were used to test the ability of retinoids to modulate cell proliferation and differentiation. In addition, antiinflammatory properties were assessed. Binding and transactivation assays were used to compare affinities and transcriptional activities of adapalene and tretinoin for the nuclear transcription factors, retinoic acid receptors (RARs). RESULTS AND CONCLUSION: Adapalene is a stable naphthoic acid derivative with potent retinoid pharmacology, controlling cell proliferation and differentiation. In addition it has significant antiinflammatory action. The nuclear gene transcription factors RAR beta and RAR gamma mediate the retinoid activity of adapalene.

DrugBank Data that Cites this Article

Drug Targets
DrugTargetKindOrganismPharmacological ActionActions
AdapaleneRetinoic acid receptor alphaProteinHumans
Unknown
Not AvailableDetails
AdapaleneRetinoic acid receptor betaProteinHumans
Yes
Agonist
Details
AdapaleneRetinoic acid receptor gammaProteinHumans
Yes
Agonist
Details
AdapaleneRetinoic acid receptor RXR-alphaProteinHumans
Yes
Agonist
Details
AdapaleneRetinoic acid receptor RXR-betaProteinHumans
Yes
Agonist
Details
AdapaleneRetinoic acid receptor RXR-gammaProteinHumans
Yes
Agonist
Details
IsotretinoinRetinoic acid receptor alphaProteinHumans
Unknown
Other/unknown
Details