Identification and characterisation of a novel splice variant of the human CB1 receptor.
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Ryberg E, Vu HK, Larsson N, Groblewski T, Hjorth S, Elebring T, Sjogren S, Greasley PJ
Identification and characterisation of a novel splice variant of the human CB1 receptor.
FEBS Lett. 2005 Jan 3;579(1):259-64.
- PubMed ID
- 15620723 [ View in PubMed]
- Abstract
Cannabinoid ligands are implicated in many physiological processes and to date two receptors have been identified. However, a growing body of evidence exists that suggests the presence of additional receptors. Whilst cloning the previously described hCB1a, we have identified a novel variant that we call hCB1b. Characterising these two splice variants demonstrates that they have a unique pharmacological profile and that their RNA's are expressed at low levels in a variety of tissues.