Interethnic differences in drug response: the contribution of genetic variability in beta adrenergic receptor and cytochrome P4502C9.

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Muszkat M

Interethnic differences in drug response: the contribution of genetic variability in beta adrenergic receptor and cytochrome P4502C9.

Clin Pharmacol Ther. 2007 Aug;82(2):215-8. Epub 2007 Feb 28.

PubMed ID

17329986 [ View in PubMed

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Abstract

Ethnic differences in drug response have been extensively reported, and ethnicity has been suggested to be useful clinically as a predictor of drug response. Genetic polymorphisms in the genes encoding beta(1) adrenergic receptor (AR) and beta(2) AR, targets of beta AR antagonists, and in cytochrome P4502C9, the enzyme involved in warfarin metabolism, have the potential to explain some of the observed ethnic variability in drug response and to improve clinical practice.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Isoetharine	Beta-1 adrenergic receptor	Protein	Humans	Yes	Agonist	Details