cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed.

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Loeffen JL, Triepels RH, van den Heuvel LP, Schuelke M, Buskens CA, Smeets RJ, Trijbels JM, Smeitink JA

cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed.

Biochem Biophys Res Commun. 1998 Dec 18;253(2):415-22.

PubMed ID
9878551 [ View in PubMed
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Abstract

NADH:ubiquinone oxidoreductase (complex I) is an extremely complicated multiprotein complex located in the inner mitochondrial membrane. Its main function is the transport of electrons from NADH to ubiquinone, which is accompanied by translocation of protons from the mitochondrial matrix to the intermembrane space. Human complex I appears to consist of 41 subunits of which 34 are encoded by nDNA. Here we report the cDNA sequences of the hitherto uncharacterized 8 nuclear encoded subunits, all located within the hydrophobic protein (HP) fraction of complex I. Now all currently known 41 proteins of human NADH:ubiquinone oxidoreductase have been characterized and reported in literature, which enables more complete mutational analysis studies of isolated complex I-deficient patients.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrialO95299Details
NADH dehydrogenase [ubiquinone] 1 subunit C2O95298Details
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10O96000Details
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3O43676Details
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4O95168Details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7O95182Details
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrialO95178Details
Acyl carrier protein, mitochondrialO14561Details
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrialO95169Details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3O95167Details